1. What is a CALR Mutation Test?
The CALR Mutation Test checks for changes in the CALR gene, which are found in some myeloproliferative neoplasms. It is a molecular diagnostic tool that identifies specific gene mutations to assist in accurate diagnosis, especially when other common mutations are not present.
2. Why is a CALR Mutation Test done?
This test is essential for diagnosing blood cancers like ET or PMF in patients who don’t have the JAK2 or MPL gene mutations. It helps doctors confirm the diagnosis, classify the disease accurately, and determine the most appropriate course of treatment and monitoring.
3. How is the CALR Mutation Test done?
A blood sample is collected from a vein and sent to a specialized lab where DNA is analyzed for mutations in the CALR gene using molecular methods like PCR or sequencing. The procedure is safe, simple, and typically completed without any major discomfort or complications.
4. Who Should Get a CALR Mutation Test?
People with unexplained elevated platelet counts, enlarged spleen, fatigue, or other symptoms related to blood cell overproduction may be candidates. It is especially recommended if JAK2 and MPL mutations are not detected in individuals suspected to have myeloproliferative disorders.
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5. Why is it necessary to take the CALR Mutation Test?
The CALR Mutation Test helps diagnose specific blood cancers and ensures patients receive the most effective and tailored treatment. It also assists in disease classification and prognosis, helping clinicians make informed decisions for long-term monitoring and care.
6. How is the CALR Mutation Test done?
A healthcare provider collects a blood sample, which is then tested in a molecular diagnostics lab. The lab uses techniques like PCR to check for mutations in the CALR gene linked to myeloproliferative diseases.
7. For Whom Should the CALR Mutation Test Be Considered?
Anyone with signs of a myeloproliferative disorder like persistent high platelet counts or splenomegaly should consider this test, especially if other common mutations (JAK2, MPL) have tested negative.
8. For whom symptoms or conditions require for monitoring?
Patients diagnosed with or suspected of having essential thrombocythemia or primary myelofibrosis require CALR Mutation monitoring to confirm diagnosis, guide treatment, and monitor progression or response to therapies over time.
Need for the CALR Mutation Test
Detecting CALR gene mutations is vital for accurate diagnosis and personalized treatment of specific blood cancers.
1. Accurately Diagnoses Myeloproliferative Neoplasms :- CALR mutations are found in a significant number of patients with ET or PMF, helping diagnose the disease when JAK2 or MPL mutations are absent.
2. Guides Precision Medicine and Treatment :- Knowing the mutation type helps doctors customize treatment strategies, which may differ depending on the genetic driver of the blood disorder.
3. Aids in Prognosis and Disease Monitoring :- CALR mutation types are associated with different disease outcomes, making the test valuable for long-term monitoring and predicting disease progression.
4. Reduces Need for Invasive Testing :- A simple blood test can provide critical genetic information, potentially reducing the need for bone marrow biopsies in early stages.
5. Supports Early Intervention and Management :- Early detection through CALR mutation testing allows for proactive monitoring and medical intervention, improving patient outcomes and quality of life.
Why Choose mediSuggest?
Expert genetic testing with assured quality, convenience, and support only on mediSuggest.
1. Trusted Network of NABL-Accredited Labs :- Our partners exclusively with NABL-accredited labs using advanced molecular diagnostic technology to ensure highly accurate, reliable, and safe CALR gene mutation testing across multiple Indian cities.
2. Easy and Hassle-Free Online Booking :- Schedule your CALR Mutation Test effortlessly through our website or app. Our simple booking process eliminates waiting lines, paperwork, and confusion, ensuring a smooth diagnostic experience from start to finish.
3. Timely and Accurate Test Results :- Get quick and dependable CALR test reports within the recommended time frame. Timely reporting helps guide early medical decisions crucial for managing complex blood-related disorders effectively.
4. Post-Test Medical Support and Guidance :- After receiving your results, consult with experienced oncologists or hematologists through us. Understand your report clearly and get personalized medical advice for your condition and future treatment steps.
5. Transparent Pricing with No Hidden Costs :- Our pricing is clear and upfront. Choose from affordable test packages with no hidden fees, ensuring peace of mind, transparency, and excellent value for high-quality diagnostic care.
Advantages of Choosing mediSuggest
Reliable genetic testing, professional support, and seamless care all in one place with mediSuggest.
1. Accurate CALR Mutation Detection :- We use high-sensitivity molecular diagnostic methods capable of detecting even low-level CALR mutations, ensuring every important genetic variation is identified for accurate diagnosis and effective treatment planning.
2. Quick Access to Specialist Care :- After your CALR test results are ready, we help arrange consultations with top hematologists. Get expert interpretation and medical guidance to understand your condition and determine the next steps.
3. Secure and Confidential Report Handling :- Your test data is protected with top-level encryption. We prioritize your privacy, ensuring secure access, storage, and sharing of your genetic information only with your explicit medical consent.
4. Expert-Curated Lab Partners Only :- We work exclusively with vetted, expert-reviewed labs that follow strict diagnostic protocols. This ensures you receive trustworthy, high-quality CALR genetic testing for informed healthcare decisions.
5. Customizable Re-testing Services :- If you require ongoing CALR mutation monitoring, we offer flexible re-testing options. Easily book follow-up tests as recommended by your doctor, with support every step of the way.
6. Dedicated Patient Support Team :- Our trained support team is always available to help with bookings, test information, or result-related queries—ensuring a seamless, reassuring experience throughout your diagnostic journey.
Frequently Asked Questions
What happens if the test is positive?
A positive result means a CALR mutation is present. Your doctor will use this information to plan appropriate treatment or monitoring based on your condition.
How long does it take to get the CALR Mutation Test results?
Results typically take 5–10 days. At MediSuggest, we ensure timely updates and notifications so you receive your report as soon as it’s ready.
What is the CALR Mutation Test used for?
It is used to detect mutations in the CALR gene, helping diagnose myeloproliferative neoplasms like essential thrombocythemia and primary myelofibrosis in patients lacking JAK2 or MPL mutations.